General description of Zyban Zyban, also known by its generic name Bupropion, is a prescription medication primarily used to help individuals in the United States quit smoking. This medication belongs to a class of drugs called antidepressants, specifically a norepinephrine-dopamine reuptake inhibitor (NDRI). Zyban works by influencing neurotransmitters in the brain, which can help reduce the urge to smoke and ease withdrawal symptoms. One of the key advantages of Zyban is that it can also …